Toshinari Mikami PhD, DDS, Researcher, Educator, and Entrepreneur

Business Career

2019 – present
CEO, Pax Creation Singapore, Pte Ltd

2018 – present
CEO, Pax Creation Medical Lab. LCC

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Academic Society

The Japanese Society of Pathology (councilor)

The Japanese Society of Oral Pathology (councilor)

Japanese Association for Oral Biology (councilor)

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Journal Editor

Associate editor of “Frontiers in Oral Health, Oral Cancer”

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Refereed International Journals

BMC Cancer, Cell Tissue Research, International Journal of Molecular Sciences, Clinical Oral Implant Research, Critical Reviews in Oncology/Hematology, International Wound Journal, Journal of Indian Society of Periodontology, Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal of Oral Pathology and Medicine, Journal of Oral Rehabilitation, Journal of Oral Science, Journal of Periodontology, Journal of Photochemistry & Photobiology, B: Biology, Onco Targets and Therapy, Oral Diseases, Pathology Research and Practice, The American Journal of the Medical Sciences, Tumor Biology, World Journal of Surgical Oncology, etc

Proefessional Experience

2018 – present
Visiting Professor, China Medical University (in China)

2017 – 2018
Adjunct Faculty, Iwate Medical University, School of Medicine

2016 – 2018
External Tutor, Postgraduate School, University of Uruguay Republic

2013 – 2018
Associate Professor, Iwate Medical University

2010 – 2013
Assistant Professor, Iwate Medical University

2010 – 2013
Adjunct Faculty, Iwate Medical University Vocational College of Medicine

2008 – 2009
Postdoctoral Researcher, Karolinska Institutet, Stockholm, Sweden

2006 – 2008
Adjunct Faculty, Iwate Medical University Vocational College of Medicine

2005 – 2010
Research Associate, Iwate Medical University

Area of Expertise

Field of Oral and Maxillofacial Pathology
(Anatomical Pathology / Experimental Pathology)
Specialized area: Odontogenic Tumors, TMJ diseases, Gene Diagnosis)

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Award

2016
“The Best Relevance Award” 18th International Congress on Oral Pathology and Medicine (Chennai, India)

2008
“Chairman Special Award for Young Investigator” 65th Dental Academic Meeting in Iwate Medical University

2005
“Japanese Journal of Pediatric Dentistry Academic Paper Award in 2004” Japanese Society of Pediatric Dentistry

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Education and Degree

2005
Ph. D. in Pediatric Dentistry, Iwate Medical University

2001
D.D.S. (Doctor of Dental Surgery)
Dental Qualification Number in Japan, #143797

2001
Bachelor of Dental Science
School of Dentistry, Iwate Medical University

Research Grant (PI)

2017-2020
“Development of Gene Diagnosis System for Odontogenic Tumors”
Japan Society for the Promotion of Science, KAKENHI Grant Number l 7Kl 1917
(Ministry of Education, Culture, Sports, Science and Technology-Japan)

2016-2018
“Establishment of Genomic Pathology for Dentistry”
Japanese Association for Dental Science, Project Research Grant B
(A multicenter project of 6 universities)

2014-2017
“Development of Diagnosis System for TMJ Disorders based on Molecular Cell Pathology” Japan Society for the Promotion of Science, KAKENHI Grant Number 26463076
(Ministry of Education, Culture, Sports, Science and Technology-Japan)

2013-2015
“Development of Pathologic Diagnosis System for TMJ Disorders and Cystic Lesions using Fluid Samples” Iwate Medical University, Shigakukai Grant (General Division)

2012-2014
“Development of Pathologic Diagnosis System for TMJ Diseases using Joint Lavage Fluid” Japan Society for the Promotion of Science, KAKENHI Grant Number 24 792251
(Ministry of Education, Culture, Sports, Science and Technology-Japan)

2001-2005
Japan Scholarship Foundation Scholarship for Graduate Students (Scholarship)

Invited Lecture

2018
“Odontogenic Tumors”
Research Symposium at China Medical University (Shenyang, China)

2018
“Introduction of primordial odontogenic tumor: Pathogenesis and clinicopathologic features”
Liaoning Stomatological Association (Liaoning, China)

2018
“Microenvironment of odontogenic tumor, development and EMT”
Joint International Associationof Oral and Maxillofacial Pathologists (IAOP) and American Academy of Oraland Maxillofacial Pathology (AAOMP) (Vancouver, Canada)

2018
“Microenvironment of odontogenic tumor, development and EMT”
Research Symposium at University of Bilbao (Spain)

2016
“Gene analysis of oral tumors and development of a genetic diagnosis system”
Research Symposium at Automonas Metropolitana University (Mexico)

2016
“Pathogenesis of Oral Cancer and Genetic Diagnosis for Future”
Research Symposium at University of Uruguay Republic (Uruguay)

2013
“Pathologic diagnosis for TMJ disorder and variety of pathology based on joint lavage fluid” 31st Annual Meeting of Academy of the Clinical Dentistry (Japan)

2010
“The process to researching in Sweden and how the research life is.” 69th Dental Academic Meeting in Iwate Medical University

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Presentation at International Conference (First presenter)

Mikami T, Bologna-Molina R, Kitagawa M, Takata T, Takeda Y: Heterogeneity ofameloblastoma on cell lines and tissue specimens originated from a single patient. 18th International Congress on Oral Pathology and Medicine, Chennai (India), 2016

Mikami T, Mizuki H, Takeda Y: Synovial sarcoma of the lip. 17th International Congress on Oral Pathology and Medicine, Istanbul (Turky), 2014

Mikami T, Takeda Y: Congenital peripheral compound odontoma in a 2-year-old patient: report of a case. 11th Congress of the European Academy of Pediatric Dentistry, Strasbourg (France), 2012

Mikami T, Aomura T, Kumagai A et al: Pathogenesis of synovial chondromatosis of the temporo­mandibular joint. 88th International Association for Dental Research, Barcelona (Spain), 2010

Mikami T, Tanaka M, Takeda Y: Remineralization of human enamel by fluoride admixed with xylitol. 84th International Association for Dental Research, Brisbane (Australia), 2006

Mikami T, Tanaka M, Takeda Yet al: Combined effects ofxylitol and a low concentration of fluid on promotion ofremineralization of human enamel, an experimental study. International Symposium of Maxillofacial & Oral Regenerative Biology in Okayama, Okayama (Japan), 2005

Mikami T, Asakawa T, Tanaka M: Remineralizing effect of enamel evaluation system based on fluoride equivalence. 82th International Association of Dental Research, Hawaii (USA), 2004

Mikami T, Asakawa T, Tanaka M: Comparative study on remineralizing effects of three kinds of xylitol chewing gum. 81 th International Association for Dental Research, Goteborg (Sweden), 2003

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Presentation at Domestic Conference (First presenter)

三上俊成，Bologna-Molina R，武田泰典．Primordial Odontogenic Tumorの遺伝子および臨床病理学的検討．第28回日本臨床口腔病理学会総会学術大会　2017.8.24　川越市．

三上俊成，小川郁子，高田隆，武田泰典．Detection of KRAS Missense Mutations in Adenomatoid Odontogenic Tumor．第27回日本臨床口腔病理学会総会学術大会　2016.8.12　広島市．

三上俊成，Bologna-Molina R，北川雅恵，高田隆，武田泰典．HAM(human ameloblastoma)細胞株を用いたエナメル上皮腫の細胞特性に関する検討．第26回日本臨床口腔病理学会総会学術大会　2015.7.30　札幌市．

三上俊成，武田泰典．次世代シーケンスを用いたホルマリン固定パラフィン標本からの遺伝子診断に関する検討．岩手医科大学歯学会第40回総会　2014.12.6　盛岡市．

三上俊成，見明康雄，武田泰典．大理石骨病患者における下顎智歯部歯槽骨の形態学的解析．第56会歯科基礎医学会学術大会　2014.9.27　福岡市．

三上俊成，千葉高大，青村知幸，水城春美，熊谷章子，武田泰典．嚢胞内容液のcell block tissue array標本を用いた低侵襲病理診断方法の考察．第25回日本臨床口腔病理学会総会学術大会　2014.8.30　新潟市．

三上俊成，水城春美，武田泰典．口腔領域原発の滑膜肉腫でみられた非定型部位における融合遺伝子の同定．岩手医科大学歯学会第77回例会　2014.7.5　盛岡市．

三上俊成，熊谷章子，青村知幸，杉山芳樹，水城春美，武田泰典．顎関節洗浄液のcell block tossue array標本を用いた顎関節症の病態診断．第24回日本臨床口腔病理学会総会学術大会　2013.8.29　東京．

三上俊成，熊谷章子，青村知幸，杉山芳樹，水城春美，武田泰典．関節洗浄液の病理検査による顎関節病変の新たな診断法．第25回日本顎関節学会総会学術大会　2012.7.14　札幌市．

三上俊成，羽田朋弘，水城春美，武田泰典．口腔領域の腫瘍におけるWT1の発現解析、扁平上皮癌について．第53回歯科基礎医学会学術大会　2011.10.2　岐阜市．

三上俊成，熊谷章子，青村知幸，杉山芳樹，水城春美，武田泰典．病理組織学的分析による顎関節症の診断および治療の新たな可能性．岩手医科大学歯学会第36回総会　2010.12.4　盛岡市．

三上俊成，青村知幸，熊谷章子，大平明範，水城春美，杉山芳樹，武田泰典．顎関節滑膜軟骨腫症の病理学的検討．岩手医科大学歯学会第35回総会　2009.12.5　盛岡市．

三上俊成，畠山節子，武田泰典．口腔ケラチノサイトにおけるconnexinの発現に対するレチノイン酸の影響．第50回歯科基礎医学会学術大会　2008.9.24　東京．

三上俊成，原田博史，武田泰典．メラニン色素沈着を伴った扁平上皮癌の免疫組織学的検討．第19回日本臨床口腔病理学会総会学術大会　2008.8.21　東京．

三上俊成，笹森傑，古内秀幸，杉山芳樹，武田泰典．メラニン色素沈着を伴った扁平上皮癌の二例：免疫組織学的分析．岩手医科大学歯学会第65回例会　2008.2.23　盛岡市．

Research Paper
(International Journal)

(New) Kuga T, Inoue N, Sometani K, Murataka S, Saraya M, Sugita R, Mikami T et al: The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton. Sci Rep. 12:11819. doi: 10.1038/s41598-022-16153-y. 2022

(New) Ali D, AlAhmari F, Mikami T, Baskaradoss JK. Increased expression of advanced glycation endproducts in the gingival crevicular fluid compromises periodontal status in cigarette-smokers and waterpipe users. BMC Oral Health. 22:206. doi: 10.1186/s12903-022-02240-z. 2022

(New) Mikami T, González-Arriagada WA, Niklander SE et al: Editorial: Odontogenic Tumors. Front Oral Health. 3:845557. doi: 10.3389/froh.2022.845557. eCollection 2022

Kayamori K, Tsuchiya M, Michi Y, Kuribayashi A, Mikami T et al: Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis. Pathol Int. 71:80-87. doi: 10.1111/pin.13036. 2020

Ishikawa T, Terashima J, Shimoyama Y, Ohashi Y, Mikami T et al: Effects of butyric acid, a bacterial metabolite, on the migration of ameloblastoma mediated by laminin 332. J Oral Sci. 62:435-438. doi: 10.2334/josnusd.19-0380. 2020

Bologna-Molina R, Ogawa I, Mosqueda-Taylor A, Takata T, Sánchez-Romero C, Villarroel-Dorrego M, Takeda Y, Mikami T. Detection of MAPK/ERK pathway proteins and KRAS mutations in adenomatoid odontogenic tumors. Oral Dis.25:481-487. doi: 10.1111/odi.12989. 2019

Mikami T, Bologna-Molina R, Mosqueda-Taylor A et al:Pathogenesis of primordial odontogenic tumour based on tumourigenesis and odontogenesis. Oral Dis. 24:1226-1234. doi: 10.1111/odi.12914. 2018

Mikami T, Ohashi Y, Bologna-Molina R et al: Primordial Odontogenic Tumor: A case report with histopathological analyses. Pathol Int. 67:638-43, 2017

Mizuki H, Abe R, Mikami T. Ultrastructural Changes during the Life Cycle ofMycoplasma salivarium in Oral Biopsies from Patients with Oral Leukoplakia. Front Cell Infect Microbial. 7:403. doi: 10.3389/ fcimb.2017.00403. eCollection 2017

Takizawa N, Okubo N, Kamo M, Chosa N, Mikami T et al: Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture. Exp Cell Res. 358:411-420, 2017

Mizuki H, Abe R, Kogi S, Mikami T: Immunohistochemical detection ofMycoplasma salivarium in oral lichen planus tissue. J Oral Pathol Med. 46:649-56, 2017

Bologna-Molina R, Mikami T, Pereira-Prado Vet al: Primordial odontogenic tumor: An immunohisto­chemical profile. Med Oral Pathol Oral Bucal. 22:e314-23, 2017

Bologna-Molina R, Takeda Y, Kuga T, Chosa N, Kitagawa M, Takata T, Ishisaki A, Mikami T: Expression ofWilms’ tumor 1 (WTl) in ameloblastomas. J Oral Sci. 58:407-13, 2016

Mikami T, Miake Y, Bologna-Molina R et al: Ultrastructural Analyses of Alveolar Bone in a Patient With Osteomyelitis Secondary to Osteopetrosis: A Review of the Literature. J Oral Maxillofac Surg. 74:1584-95, 2016

Kuga T, Sasaki M, Mikami T et al: FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes. Sci Rep. 6, 26557; doi: 10.1038/srep26557, 2016

Javed F, Ahmed HB, Mehmood A, Mikami T et al: Self-perceived oral health and periodontal parameters in chronic periodontitis patients with and without rheumatoid arthritis. J Investig Clin Dent. 7 :53-8, 2016

Mikami T, Kurose A, Javed F et al: Detection of Rare Variant of SS18-SSX1 Fusion Gene and Mutations oflmportant Cancer-Related Genes in Synovial Sarcoma of the Lip: Gene Analyses of a Case and Literature Review. J Oral Maxillofac Surg. 73:1505-15, 2015

(Book) Takeda Y, Mikami T, Fukuta Yohko: Tyrosine-rich crystalloids in pleomorphic adenoma: a case report. Oral Science in Japan 2015, p.101-2, 2015

(Book) Takeda Y, Mikami T, Fukuta Yohko: A familial case ofnevoid basal cell carcinoma syndrome with pigmented keratocystic odontogenic tumors. Oral Science in Japan 2015, p.113-4, 2015

Javed F, Al-Kheraif AA, Al Amri MD, Mikami T et al: Periodontal parameters and whole salivary cytokine profiles among habitual gutka chewers and non-chewers. J Periodontal. 86:689-95, 2015

Mikami T, Kumagai A, Aomura T et al: Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders: Diagn Cytopathol. 42:30-6, 2014

Javed F, Ahmed HB, Mikami T et al: Cytokine profile in the gingival crevicular fluid ofrheumatoid arthritis patients with chronic periodontitis. J Investig Clin Dent. 5: 1-8, 2014

Javed F, Thafeed Alghamdi AS, Mikami T et al: Effect of glycemic control on self-perceived oral health, periodontal parameters, and alveolar bone loss among patients with prediabetes. J Periodontal. 85:234-41, 2014

Mikami T, Hada T, Chosa Net al: Expression of Wilms’ tumor 1 (WTI) in oral squamous cell carcinoma. J Oral Pathol Med. 42:133-9, 2013

Mikami T, Yagi M, Mizuki H et al: Congenital peripheral developing odontoma accompanied by congenital teratomatous fibroma in a 9-month-old boy: a case report. J Oral Sci. 55:89-91, 2013

Javed F, Alghamdi AS, Ahmed A, Mikami T et al: Clinical efficacy of antibiotics in the treatment of peri-implantitis. Int Dent J. 63:169-76, 2013

Mikami T, Aomura T, Ohira A et al: Three case reports of synovial chondromatosis oftemporo­mandibular joint: Histopathologic analyses of minute cartilaginous loose bodies from joint lavage fluid and comparison with phase II and III cases. J Oral Maxillifac Surg. 70:2099-105, 2012

Mikami T, Furuya I, Kumagai A et al: Pigmented squamous cell carcinoma of the oral mucosa: clinicopathological study of three cases. J Oral Maxillifac Surg. 70:1232-9, 2012

Hatakeyama S, Mikami T, Habano Wet al: Expression of connexins and the effect ofretinoic acid in oral keratinocytes. J Oral Sci. 53:327-32, 2011

Mikami T, Takeda Y, Ohira A et al: Tumoral calcium pyrophosphate dihydrate crystal deposition disease of the temporomandibular joint: identification on crystallography. Pathol Int. 58:723-9, 2008

Mikami T, Saito M, Matsumoto H et al: Reliability of clinical diagnosis and DIAGNOdent TM measurement value for dental caries comparing with results of contact microradiographic examinations. Dent J Iwate Med Univ. 32:57-65, 2007

Hatakeyama S, Yaegashi T, Oikawa Y, Fujiwara H, Mikami T et al: Expression pattern of adhesion molecules in the junctional epithelium differes from that in other gingival epithelia. J Periodont Res. 41 :322-8, 2006

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Research Paper
(Domestic Journals)

武田泰典，杉山ちか子，福田容子，三上俊成，中屋敷修．ヒト永久歯の歯質吸収に関する古くて新しい疑問．みちのく歯学会雑誌 2015；46（1/2）：5-6．

羽田朋弘，三上俊成．多形腺腫における腫瘍性筋上皮細胞マーカーとしてのWT1の有用性に関する検討．岩手医科大学歯学雑誌2011；36（1）：1-18．

Mikami T，Saito M，Matsumoto H，Ryokawa A，Tanaka M，Takeda Y．Reliability of clinical diagnosis and DIAGNOdent TM measurement value for dental caries comparing with results of contact microradiographic examinations. 岩手医科大学歯学雑誌 2007;32:57-65．

三上俊成．フッ化物配合キシリトールガムの再石灰化促進効果．小児歯科学雑誌 2005；43（1）：1-11．

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Book and Chapter

武田泰典，三上俊成．共著．腫瘍類似病変　腫瘍病理鑑別診断アトラス　頭頸部腫瘍Ⅱ．東京：文光堂.

武田泰典，三上俊成．共著．腫瘍類似病変　腫瘍病理鑑別診断アトラス　頭頸部腫瘍Ⅱ．東京：文光堂.2015：214-217.

Takeda Y，Mikami T, Fukuta Y．共著．Tyrosine-rich crystalloids in pleomorphic adenoma: a case report．Oral Sci Jpn 2015．東京：（NPO）日本口腔科学会.2015：101-102.

Takeda Y，Mikami T, Fukuta Y．共著．A familial case of nevoid basal cell carcinoma syndrome with pigmented keratocystic odontogenic tumors．Oral Sci Jpn 2015．東京：（NPO）日本口腔科学会.2015：113-114.

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Invited Review

武田泰典，三上俊成．歯原性嚢胞（歯原性腫瘍との鑑別の要点）．病理と臨床,2013；31（5）:521-526．

武田泰典，三上俊成．顎骨腫瘍の病理．臨床画像,2010；26（3）:249-262．